ABSTRACT
Tumor angiogenesis is closely related to the biological behavior of tumor tissue.Microvessel density is the gold standard to evaluate tumor angiogenesis,but it is invasive.Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI),a robust imaging method,is commonly used to non-invasively characterize changes in tumor vascularity and to assess the therapeutic effect of anticancer strategies.This review introduces the DCE-MRI and its current application in the diagnosis and treatment of tumor.
ABSTRACT
Objective To study the feasibility of DCE-MRI application in the orthotopic transplantation model of gastric cancer in nude mice.Methods Orthotopic transplantation model of gastric cancer in nude mice was established, and 15 models underwent DCE-MRI using the contrast agent of gadopentetate.Subsequently, the tumor was dissected in order to detect the MVD.The MVD was compared between orthotopic transplantation tumor model of gastric cancer and normal gastric mucosa.Results Fifteen nude mice with orthotopic transplantation of gastric cancer successfully underwent DCE-MRI examination.As for the cancer, the values of Ktrans, Kep and Ve were (2.11±0.44) min-1, (4.59±0.93) min-1, and 0.46±0.06, respectively.The MVD in gastric cancer tissues was significantly higher than that in normal gastric mucosa (χ2=16.205, P<0.001).Conclusion DCE-MRI can be used for noninvasively quantitative evaluation of vascular parameters of gastric carcinoma.
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Hydromorphone(HM),appeared in the Chinese market in 2013 is a more potent opioid analgesic than morphine and is used for moderate to severe pain. Micro-invasive drug administration methods,including continuous infusion and patientcon?trolled analgesia(PCA),will provide hopes for controlling the outbreak of pain and improving patients' satisfaction. At present ,hydro?morphone is the most commonly used drug for the treatment of acute pain,chronic pain and cancer pain. However,we should also con?sider the stability and compatibility of hydromorphone in the implantable infusion system that is most commonly used in these patients. The purpose of this paper is to review the clinical application and stability(changes in color,pH and concentration)of hydromor?phone in different infusion systems so as to provide the basis of rational clinical application.
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Objective To assess the feasibility of K value of dynamic contrast enhanced MRI (DCE-MRI) in evaluation of anti-angiogenic effects on nude mice with orthotopic transplantation tumor model of gastric cancer.Methods Nude mice with orthotopic transplantation tumor model of gastric cancer were randomly assigned to two groups:Treatment group (n =15),mice were given apatinib intragastrically for 18 days (100 mg/kg),and control group (n=15),mice were given ddH2O2 in the same manner.After 18 days,DCE-MRI was performed and K value was measured.Then the tumors were dissected from the adjacent tissues in order to detect the microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression levels.MVD and VEGF expression level were compared between treatment group and the control group.Results MVD (x2 =4.89,P＜0.05) and VEGF expression level (x2 =8.69,P＜0.01) of treatment group were much lower than those of control groups.The Kt value of treatment group was significantly lower than that of control groups ([0.63±0.05]/min vs [1.66±0.23]/min,t=17.05,P＜0.01).Conclusion The value of k in DCE-MRI can be utilized to assess the effects of apatinib on nude mice with orthotopic transplantation model of gastric cancer.
ABSTRACT
Objective To observe the clinical effect of health education pathway on patients after hip replacement. Methods Patients after artificial hip replacement (200 cases) were divided randomly into the observation group and the control group with 100 cases in each group.The control group adopted general health education methad.The observation group was given health education according to health education pathway.The level of disease-related knowledge and satisfactory degree were compared between the two groups. Results The level of disease-related knowledge and satisfactory degree in the observation group were higher than those of the control group (P ＜ 0.01 ). Conclusions Health education pathway can facilitate level of disease-related knowledge and positive cooperation with treatment and nursing of patients as well as increase satisfactory degree of patients.